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Understanding the Increased Risk of Cardiovascular Disease in People With HIV

NCT00577681 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 5472

Last updated 2019-11-01

No results posted yet for this study

Summary

HIV is a virus that can lead to acquired immunodeficiency syndrome (AIDS), a disease for which there is not yet a cure. Antiretroviral therapy (ART) has proven an effective treatment for inhibiting the replication of HIV, allowing for improved quality of life and survival. Previous studies indicate that episodic use of ART is associated with increased risk of cardiovascular disease (CVD). This study will determine mechanisms underlying the increased CVD risk among people infected with HIV and, specifically, in those who receive episodic ART.

Conditions

  • HIV Infections

Interventions

DRUG

Antiretroviral Therapy (ART)

Either episodic ART or continuous ART. All groups will have plasma specimens taken to compare changes in lipoprotein particle sizes and numbers and changes in inflammatory and coagulation markers.

Sponsors & Collaborators

Principal Investigators

  • Daniel A. Duprez, MD, PhD · University of Minnesota

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2002-01-31
Primary Completion
2006-01-31
Completion
2006-01-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00577681 on ClinicalTrials.gov