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TF, TFPI and Plasmin as Novel Bio-markers in Early Diagnosis of Lupus Nephritis

NCT04218890 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2020-01-07

No results posted yet for this study

Summary

Urinary levels of plasmin ,TF , and TFPI are all elevated in active LN patients compared to inactive LN patients and healthy controls. All four proteins correlated with systemic disease activity and renal disease activity. Importantly, urine plasmin performed best among the four proteins in discriminating active LN from inactive disease, even better than traditional markers, such as anti ds DNA and complement C3. Furthermore, the combination of urine plasmin and TFPI showed higher specificity and negative predictive values than urine plasmin when compared to anti-ds DNA and complement C3

Conditions

Interventions

DIAGNOSTIC_TEST

Urinary tissue factor (TF), tissue factor pathway inhibitor (TFPI) and plasmin

urinary sample

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Eligibility

Min Age
15 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-04-01
Primary Completion
2023-04-01
Completion
2023-12-01

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04218890 on ClinicalTrials.gov