Transition to LIVE (Long-term In Home Ventilation Engagement) Study

Summary

The rising prevalence of ventilator assisted individuals (VAIs) who depend on Home Mechanical Ventilation (HMV) is an escalating public health challenge with important social and economic implications. VAIs are high cost users of the healthcare system, requiring competent healthcare and family caregivers for successful transition to HMV. The TTLive Study will evaluate the effect of a virtual transition intervention delivered through a virtual care platform, compared to usual care on emergent healthcare utilization, caregiver burden, health cost-effectiveness including cost of family caregiver time, and efficiency of clinical encounters for individuals newly transitioning to HMV.

Conditions

• Long-term Ventilation at Home

Interventions

DEVICE

aTouchAway™ platform

Participants will receive multi-component Virtual Transition Intervention. The four components of the intervention comprise: (1) routine virtual clinic visits scheduled at the same frequency as usual care; (2) virtual care plan and action plan for respiratory infection/deterioration and management of ventilator issues; (3) remote, weekly and monthly monitoring of ventilator and cough assist metrics, VAI symptoms, and oxygen saturations; and (4) as needed clinical consultations triggered by identification of abnormal parameters or requested by the VAI or family caregiver.

Sponsors & Collaborators

• West Park Healthcare Centre

  collaborator OTHER

• The Ottawa Hospital

  collaborator OTHER

• Sunnybrook Health Sciences Centre

  collaborator OTHER

• London Health Sciences Centre

  collaborator OTHER

• Children's Hospital of Eastern Ontario

  collaborator OTHER

• McMaster Children's Hospital

  collaborator OTHER

• Kingston Health Sciences Centre

  collaborator OTHER

• Aetonix Systems

  collaborator UNKNOWN

• The Hospital for Sick Children

  lead OTHER

Principal Investigators

• Reshma Amin, MD, MSc · The Hospital for Sick Children

• Louise Rose, PhD · King's College London

• Andrea Gershon, MD, MSc · Sunnybrook Health Sciences Centre

Study Design

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

SINGLE

Model

PARALLEL

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-03-01

Primary Completion

2026-01-30

Completion

2026-01-30

Countries

• Canada

Study Locations