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Home Mechanical Ventilation vs Home Oxygen Therapy in COPD

NCT00990132 · Status: COMPLETED · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 116

Last updated 2016-05-13

No results posted yet for this study

Summary

This study is designed to investigate the effect of home mechanical ventilation (HMV) in patients with severe chronic obstructive pulmonary disease (COPD). The purpose of the trial is to test the hypothesis that HMV and longterm oxygen therapy (LTOT) increases admission free survival compared with LTOT alone. More specifically, compared with LTOT, HMV and LTOT reduces hospital re-admission in COPD patients who remain persistently hypercapnic following an acute exacerbation requiring non-invasive ventilation (NIV).

Conditions

Interventions

DEVICE

Home mechanical ventilation

Nocturnal non-invasive ventilation

DEVICE

Long term oxygen therapy

LTOT established as per national guidelines

Sponsors & Collaborators

  • Guy's & St Thomas' Charity

    collaborator OTHER

  • Respironics International

    collaborator INDUSTRY

  • ResMed

    collaborator INDUSTRY

  • ResMed Foundation

    collaborator OTHER

  • Patrick Murphy

    lead OTHER

Principal Investigators

  • Patrick Murphy, MBBS · Guy's and St Thomas' NHS Foundation Trust

  • Nicholas Hart, PhD · Guy's and St Thomas' NHS Foundation Trust

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-10-31
Primary Completion
2016-04-30
Completion
2016-04-30

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00990132 on ClinicalTrials.gov