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Serum Progesterone Levels on the Day of Frozen Embryo Transfer (FET) and Pregnancy Outcomes

NCT04170517 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 402

Last updated 2022-08-29

No results posted yet for this study

Summary

Frozen embryo transfer (FET) cycles have become more common in recent years due to a push towards elective single embryo transfer (SET). While it is known that progesterone supplementation during the luteal phase improves clinical pregnancy rates, there is a paucity of prospective data on the impact of serum progesterone levels on pregnancy outcomes in FET cycles. This multicentre prospective cohort study aims to investigate the association between serum progesterone levels on the day of FET and pregnancy outcomes, and to determine a serum progesterone cut-off value above which clinical pregnancy and live birth are more likely to occur. Women undergoing ART-FET cycles at CARE Fertility clinics in the UK will be recruited and their serum progesterone measured on the day of frozen embryo transfer. Follow-up data will be stored in electronic patient records and analysed to determine whether a low serum progesterone level on the day of FET adversely affects ART outcomes.

Conditions

Interventions

DIAGNOSTIC_TEST

Measurement of serum progesterone on the day of FET

Measurement of serum progesterone on the day of FET

Sponsors & Collaborators

  • CARE Fertility UK

    lead OTHER

Principal Investigators

  • Arri Coomarasamy, MBChB MD FRCOG · CARE Fertility UK

Eligibility

Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-01-02
Primary Completion
2021-02-28
Completion
2021-12-31

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04170517 on ClinicalTrials.gov