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Progesterone Levels and Frozen Embryo Transfer Outcomes

NCT07252622 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 659

Last updated 2025-11-28

No results posted yet for this study

Summary

Frozen embryo transfers (FET) now represent the majority of all embryo transfer cycles, and upwards of 60% live births in United States are now attributable to frozen embryo transfers (1). Exogenous progesterone for endometrial decidualization and luteal phase support is thought to be critical to both optimizing endometrial receptivity for implantation as well as sustaining early pregnancy prior to reliable secretory activity of the early placenta.

The purpose of this study is to:

1. Determine the prevalence of low serum progesterone levels (less than 10 ng/ml) among patients undergoing a programmed embryo transfer cycle on the day of frozen embryo transfer.
2. Determine if serum progesterone \< 10 ng/ml on the day of frozen embryo transfer is associated with poorer FET outcomes: ongoing pregnancy (primary outcome), live birth, biochemical pregnancy, and clinical pregnancy.

Conditions

  • IVF

Interventions

OTHER

Blood draw

All patients will have one additional blood draw on the day of their transfer to measure progesterone level.

Sponsors & Collaborators

  • Shady Grove Fertility Reproductive Science Center

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-01
Primary Completion
2028-11-01
Completion
2028-11-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07252622 on ClinicalTrials.gov