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Delirium, Intraoperative Cerebral Perfusion and EEG Abnormalities After Total Hip Arthroplasty

NCT02818764 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 3

Last updated 2020-12-23

No results posted yet for this study

Summary

The overall objective of this study is to test for perturbations in intraoperative electroencephalogram (EEG) , cerebral blood flow (CBF), cerebral metabolic rate of oxygen consumption (CMRO2), oxygen extraction fraction (OEF), and serum and cerebral spinal fluid biomarkers associated with delirium in high risk population having elective hip arthroplasty at Penn Presbyterian Medical Center (PPMC).

Conditions

  • Delirium
  • Hip Arthroplasty
  • Elderly

Interventions

PROCEDURE

Blood Draw

5 mL of blood from the patients preoperative, postoperative, 1 day and 2 days after surgery for a total of 20 mL.

PROCEDURE

Cerebral Spinal Fluid collection

Fluid collected at the time of dural puncture if patients will undergo spinal anesthesia

DEVICE

Electroencephalogram

Test used to detect abnormalities related to electrical activity of the brain will be done during surgery.

DEVICE

Cerebral blood flow and oxygen extraction fraction

NIRS measurement of Cerebral blood flow and cerebral tissue oxygen concentration.

Sponsors & Collaborators

Principal Investigators

  • Andrew W Kofke, MD MBA FCCM · University of Pennsylvania

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-06-30
Primary Completion
2020-12-31
Completion
2020-12-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02818764 on ClinicalTrials.gov