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Epinephrine and Cortisol in Depression

NCT04148261 · Status: WITHDRAWN · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL

Last updated 2021-10-06

No results posted yet for this study

Summary

This study investigates the effects of two hormones called epinephrine and cortisol on how the brain processes emotional material using functional MRI to measure brain activity. The study hopes to learn how epinephrine and cortisol affect the brain differently in depressed and non-depressed individuals.

Conditions

Interventions

DRUG

Hydrocortisone Acetate (CORT)

Participants will receive a single dose of hydrocortisone at a dosage of 0.65 mg/kg

DRUG

Epinephrine Sulfate (EPI)

Participants will receive a continuous infusion of epinephrine at a dosage of 80 ng/kg/min

DRUG

Placebo (PLB)

Participants will receive a placebo

Sponsors & Collaborators

Principal Investigators

  • Keith Sudheimer, Ph.D. · Stanford University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-12-31
Primary Completion
2022-12-31
Completion
2022-12-31

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04148261 on ClinicalTrials.gov