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HIV Exposure in Utero and Metabolic Disease Risk in HIV-Negative Young Adults

NCT04132830 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 174

Last updated 2024-09-23

No results posted yet for this study

Summary

Globally, over 1 million babies are born to mothers with HIV each year. With the advent of prenatal antiretroviral therapy, up to 98% of these individuals may be HIV-exposed uninfected (HEU). A growing literature suggests that in utero HIV exposure - even in the absence of subsequent infection - may be associated with adverse health outcomes in infancy and childhood. However, there is little information about the long-term health implications of in utero HIV exposure later in life, such as into adulthood. In this study, for the first time, we seek to prospectively evaluate metabolic and immune indices among HEU young adults as compared to well-matched HIV-unexposed uninfected controls. This study serves as a necessary first step toward optimizing clinical care for this expanding and aging HEU population, including the implementation of novel screening and prevention strategies.

Conditions

  • HIV-exposed Uninfected

Interventions

OTHER

In Utero HIV Exposure

Born to mother who had HIV infection during pregnancy.

OTHER

No In Utero HIV Exposure

Born to mother who did not have HIV infection during pregnancy.

Sponsors & Collaborators

  • Massachusetts General Hospital

    lead OTHER

Principal Investigators

  • Lindsay T Fourman, MD · Massachusetts General Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-10-01
Primary Completion
2024-07-26
Completion
2024-07-26

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04132830 on ClinicalTrials.gov