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Cardiometabolic Health of Children Exposed to Anti-retroviral Therapy (ART) in Utero

NCT04763668 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 320

Last updated 2021-05-06

No results posted yet for this study

Summary

The Human Immunodeficiency Virus (HIV) has been recently linked to increased risk for cardiovascular diseases (CVDs). The prevalence of cardiovascular diseases and its risk factor, hypertension, are very high in African communities especially in the working age group which also happens to have the bulk of young female adults in the reproductive age. Hypertension in African children is becoming a real cause for concern though its etiology remains elusive. Thanks to antiretroviral therapy (ART) use, many more infected persons live long enough to reproduce, consequently, an increasing number of children are being born to mothers who are infected with HIV. Could it be that in utero exposure of these children to HIV/ART contribute in programming them for increased risk for cardiovascular diseases thus making them more vulnerable to hypertension in childhood and adulthood? This study is aimed at exploring the possible association of in utero exposure to the HIV/ART environment and an increased risk for cardiovascular disease.

Conditions

  • In Utero Drug Exposure

Interventions

OTHER

Pregnant HIV positive women on ARTs

Cardiovascular disease risk in pregnant HIV positive women on ARTs

OTHER

Babies born to HIV positive mothers on ARTs

cardiovascular disease risk in the offspring of HIV positive mothers on ARTs

Sponsors & Collaborators

  • Nelson Mandela Academic Hospital

    collaborator UNKNOWN

  • Umtata General Hospital

    collaborator UNKNOWN

  • Medical University of Graz

    collaborator OTHER

  • Walter Sisulu University

    lead OTHER

Eligibility

Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-05-20
Primary Completion
2021-12-31
Completion
2023-12-31

Countries

  • South Africa

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04763668 on ClinicalTrials.gov