Cohort of Young Adults Infected With HIV Since Birth or During Childhood

Summary

Background: With the improvement of the prognosis for HIV-infected infants, thanks to the availability of antiretroviral therapies, young adults infected with HIV since birth are becoming an emerging group among the HIV-infected population. Morbidity, mortality and immunovirological evolution in these young adults need to be studied in a large population and compared to patients infected with HIV later in adulthood or to the general population in terms of mortality. Moreover, the study of accelerated or premature ageing, linked to HIV and/or antiretroviral therapy, is particularly interesting in this population.

Objectives: To study the transition to adulthood and the further evolution of HIV-1 or -2 perinatally infected young adults: 1) To study the teenager to adult transition in terms of clinical and immunovirological status, schooling and professional integration, sexuality and reproductive life, transition from paediatrics to adult departments; 2) To study prognosis, morbidity and mortality according to age, infection stage at the time of antiretroviral initiation and therapeutic history; 3) To study the incidence and expression of adverse events and the potential link to antiretroviral therapies; 4) To study the markers of a potential premature ageing, from the metabolic, cardiovascular and immunological points of view.

Conditions

• HIV Infection
• Young Adult

Interventions

BIOLOGICAL

blood sampling, specific biological exams and biobank and self administered questionnaires

HIV INFECTION at inclusion and annually up to 06 years follow-up 1. clinical and therapeutic evaluation by physician 2. biological: blood sampling, specific biological exams and biobank 3. self administered questionnaires In the physiopathological module: at inclusion and after 3 years follow up: OGTT, CT Scan, Dexa Scan, cardiovascular explorations (carotid intima media thickness, pulse wave velocity, transthoracic echocardiography) HIV UNINFECTED at inclusion and after 3 years follow up 1. clinical evaluation by physician 2. biological: blood sampling, specific biological exams and biobank 3. self administered questionnaires

Sponsors & Collaborators

• French National Agency for Research on AIDS and Viral Hepatitis

  lead OTHER_GOV

Principal Investigators

• Hugues Aumaitre · Centre hospitalier de Perpignan

• Eric Froguel · Hopital de Lagny

• Michèle Bentata · Hopital Avicenne

• Philippe Genet · Hopital Argenteuil

• Olivier Patey · CHIC Villeneuve St Georges

• Laurence Gerard · St Louis Paris

• Frédéric Lucht · St Etienne

• Bruno Hoen · St Jacques Besançon

• Jean Luc Schmit · Hôpital Nord Amiens

• Claire Pintado · St Louis Paris

• Cécile Goujard · Le Kremlin Bicetre

• Thierry Allegre · CH Aix en Provence

• Alain Lafeuillade · CHIC Toulon

• Pierre De Truchis · Raymond Poincarré Garches

• Vincent Jeantils · Jean Verdier Bondy

• Claudine Duvivier · Institut Pasteur

• Laurence Slama · Tenon Paris

• Olivier Bouchaud · Hopital Avicenne Bobigny

• Marie Karmochkine · Georges Pompidou Paris

• Dominique Salmon Ceron · Cochin Paris

• Emmanuel Mortier · Louis Mourier Colombes

• Roland Tubiana · Pitié Salpétrière Paris

• Pierre Marie Girard · St Antoine Paris

• André Cabié · CHU Fort de France

• Jean Marie Chennebault · University Hospital, Angers

• Philippe Morlat · St André Bordeaux

• Pierre Weinbreck · Hôpital Dupuytren

• Laurent Cotte · La Croix Rousse Lyon

• Sophie Matheron · Bichat Paris

• Véronique Reliquet · Hotel Dieu Nantes

• Philippe Pérré · CHD Les Oudairies La Roche Sur Yon

• Cédric Arvieux · Hopital Pontchaillou Rennes

• Christine Cheneau · Centre Hospitalier Strasbourg

• Martine Obadia · CH Purpan Toulouse

• Renaud Verdon · CHU Cote de Nacre Caen

• Christine Jacomet · Hopital Gabriel Montpied Clermont Ferrand

• Lionel Piroth · CHU Hopital d'enfants Dijon

• Antoine Chéret · CH TOURCOING

• Yasmine Debab · CHU Charles Nicolle Rouen

• Dominique Merrien · CH Compiègne

• Patrick Mercié · CHU St André Bordeaux

• Valérie Garrait · CHIC Créteil

• Marie Aude Khuong · Centre Hospitalier Général St Denis

• Geneviève Beck Wirth · CH Mulhouse

• Stéphane Blanche · Necker Paris

• Franck Boccara · St Antoine Paris

• Claudine Barbuat · CHR Caremeau Nimes

• Jean Paul Viard · Hotel Dieu Paris

• Ghislaine Firtion · Cochin Paris

• Albert Faye · Robert Debré Paris

• Catherine Dollfus · Armand Trousseau Paris

• Corinne Floch Tudal · Louis Mourier Colombes

• Kamila Kebaili · Hopital de jour ISHOP Lyon

• Joelle Tricoire · CHU Paule de Viguier Toulouse

• Françoise Mazingue · CHR Jeanne de Flandres Lille

• Pascal Bolot · CHG St Denis

• Francois Bissuel · CH LC Fleming St Martin Guadeloupe

• Anne Chace · CHIC Villeneuve St Georges

• Narcisse Elenga · CHG Andrée Rosemon Cayenne

• Natacha Entz Werle · Hautepierre Strasbourg

• Thomas Girard · Hotel Dieu Paris

• Martine Levine · Robert Debré Paris

• Benoit Martha · CH Chalon sur Soane

• Sandrine Anne Martha · Chalon sur Saone

• Patrice Poubeau · CHR Réunion St Pierre

• Jean Marc Treluyer · CIC Necker Paris

• Louis Bernard · Hôpital Bretonneau Tours

• Michel Dupon · Hôpital Pellegrin Bordeaux

• David Zucman · Hôpital Foch Suresnes

• Anne Simon · Pitié Salpétrière Paris

• Isabellle Poizot Martin · Ste Marguerite Marseille

• Thierry Prazuck · CHR Orléans

• Eric Doré · CHU Estains Clermont Ferrand

• Catherine Gaud · CHR Site Felix Guyon Bellepierre La Réunion

Study Design

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

25 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2010-06-30

Primary Completion

2018-12-31

Completion

2018-12-27

Countries

• France