Labelled Carbon Sucrose Breath Test (13C-SBT) as a Marker of Environmental Enteropathy

Summary

Linear growth failure, a manifestation of chronic undernutrition in early childhood, is a recalcitrant problem in resource constrained settings. The underlying causes of growth failure are multifactorial, but persistent and recurrent infection and inflammation of the gastrointestinal tract and immune activation, a condition commonly referred to as environmental enteropathy, is an important contributor. A highly enriched 13C-Sucrose Breath Test, a measure of sucrase-isomaltase activity, will be evaluated as a non-invasive biomarker of environmental enteropathy, and more specifically of intestinal brush border enzyme activity in 6 resource poor countries (Bangladesh, India, Jamaica, Kenya, Peru and Zambia) in 100 volunteers aged 12-15 months (total n=600) and evaluated relative to the lactose rhamnose test and linear and ponderal growth over a 3-6 month period following biomarker assessment. Field usability will also be assessed.

Conditions

• Glucose-Galactose Malabsorption
• Enteropathy
• Malnutrition, Child
• Intestinal Permeability
• Linear Growth Failure

Sponsors & Collaborators

• International Atomic Energy Agency

  collaborator OTHER_GOV

• Flinders University

  collaborator OTHER

• International Centre for Diarrhoeal Disease Research, Bangladesh

  collaborator OTHER

• St. John's Research Institute

  collaborator OTHER

• The University of The West Indies

  collaborator OTHER

• Mmust Masinde Muliro University of Science and Technology

  collaborator UNKNOWN

• Asociacion Benefica Prisma

  collaborator OTHER

• Scottish Universities Environmental Research Centre

  collaborator OTHER

• University of Michigan

  collaborator OTHER

• Tropical Diseases Research Centre, Zambia

  collaborator OTHER_GOV

• Gastroenterology Services, Ltd.

  collaborator OTHER

• University of Virginia

  lead OTHER

Principal Investigators

• Victor Owino, PhD · International Atomic Energy Agency

Eligibility

Min Age

12 Months

Max Age

15 Months

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-09-01

Primary Completion

2022-07-01

Completion

2022-12-31

Countries

• Australia
• Bangladesh
• India
• Jamaica
• Kenya
• Peru
• United Kingdom
• Zambia

Study Locations