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The Role of the Pregnane X Receptor (PXR) in Indole Signaling and Intestinal Permeability in Inflammatory Bowel Disease

NCT04089501 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 43

Last updated 2019-09-16

No results posted yet for this study

Summary

The goal of this study is to better understand the mechanisms responsible for the development of and the severity of Inflammatory Bowel Disease (IBD), such as Crohn's Disease and Ulcerative Colitis, which cause inflammation of the gut as well as potentially affecting other areas of the body

Conditions

  • Inflammatory Bowel Diseases

Interventions

DIAGNOSTIC_TEST

Stool collection

Stool will be collected from subjects who have been diagnosed with IBD or whom small intestinal, colonic or ileocolonic and have signed consent for the control group. Stool will be self-collected or through routine colonoscopy procedure.

DIAGNOSTIC_TEST

Biopsy collection

3 additional biopsies (for research purposes) will be taken from patients who undergo colonoscopy as per standard of care

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    collaborator NIH

  • Albert Einstein College of Medicine

    lead OTHER

Principal Investigators

  • Sridhar Mani, MD · Albert Einstein College of Medicine

Eligibility

Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-02-25
Primary Completion
2019-05-02
Completion
2019-05-02

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04089501 on ClinicalTrials.gov