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Role of the Chemical Environment in the Pathogenesis of Inflammatory Bowel Disease

NCT03376230 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 148

Last updated 2019-02-15

No results posted yet for this study

Summary

Inflammatory Bowel Diseases (IBD) including Crohn's disease and ulcerative colitis are multifactorial diseases leading to chronic inflammation of intestinal mucosa. Their etiology is still unknown. Recently, major advances in the understanding of their pathophysiology have allowed to define them as heterogenic polygenic diseases, occurring in genetically susceptible patients. However, the whole genetic susceptibility does not explain the development of IBD and several data argue in favor of the involvement of environmental factors, which remain to be identified.

The aims of this clinical trial are:

1. As main objective: To determine the effects of environmental pollutants on intestinal homeostasis and particularly on inflammatory process and endoplasmic reticulum stress.
2. As secondary objective, to assess in human the genetic susceptibility of intestinal mucosa to environmental chemical compounds (I.e. xenobiotics), its interindividual variability, and its potential involvement in the pathogenesis of IBD.

Conditions

  • Inflammatory Bowel Diseases

Interventions

OTHER

Collect of blood, urines, and intestinal biopsies

Sponsors & Collaborators

  • University Hospital, Lille

    lead OTHER

Principal Investigators

  • Pierre Desreumeaux, MD, PhD · University Hospital, Lille

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-02-28
Primary Completion
2019-01-24
Completion
2019-01-24

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03376230 on ClinicalTrials.gov