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Mucosal Innate Immune Activation in Chronic Intestinal Disorders

NCT03529318 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2019-10-22

No results posted yet for this study

Summary

Crohn's disease and ulcerative colitis are types of chronic intestinal disorder called inflammatory bowel diseases (IBD) that can affect the small and large bowel causing symptoms of abdominal pain, diarrhea, blood in the stool, and weight loss. Irritable bowel syndrome (IBS) is a milder form of IBD, with symptoms of abdominal pain, bloating, diarrhea or constipation, and blood in the stool. It is not known what causes diseases such as IBD and IBS. This study will look at the events in the gut that leads to leaky gut and inflammation in patients with IBD and IBS. The study will also see if medications such as rifaximin and mesalamine may reduce the amount of leaky gut.

Conditions

  • Irritable Bowel Syndrome
  • Inflammatory Bowel Diseases

Interventions

PROCEDURE

Biopsies from endoscopy

1\) Patients scheduled for endoscopy (EGD or colonoscopy) for IBD will be consented to allow physicians who are performing endoscopies to take additional biopsies and blood samples for "research purposes".

Sponsors & Collaborators

  • University of Arkansas

    lead OTHER

Principal Investigators

  • Benjamin Tharian, MD · University of Arkansas

  • Julia Liu, MD · University of Arkansas

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-09-01
Primary Completion
2019-10-18
Completion
2019-10-18

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03529318 on ClinicalTrials.gov