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VNS-induced Corticospinal Plasticity

NCT04088565 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 26

Last updated 2022-11-01

No results posted yet for this study

Summary

The goal of this study is to learn more about the connections between the brain, spinal cord, and muscles and how these connections can be strengthened after neurological injury.

Conditions

Interventions

OTHER

Paired-Associative Stimulation (PAS)

Simultaneous activation of connections in motor cortex via stimulation to the nerves and brain.

OTHER

Vagus Nerve Stimulation (VNS)

Recruits the auricular branch of the vagus nerve which activates brain structures that release chemicals mediating cortical plasticity.

OTHER

Sham Stimulation

Sub-threshold stimulation that does not activate neural structures.

Sponsors & Collaborators

  • University of Pittsburgh

    lead OTHER

Principal Investigators

  • George F Wittenberg, MD, PhD · University of Pittsburgh

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-09-22
Primary Completion
2021-11-09
Completion
2021-11-09

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04088565 on ClinicalTrials.gov