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Ketamine Interleaved With Electroconvulsive Therapy for Depression

NCT04082858 · Status: TERMINATED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 3

Last updated 2021-09-09

No results posted yet for this study

Summary

Pragmatic, randomised, controlled, parallel group, pilot clinical trial of ketamine vs. midazolam interleaved with electroconvulsive therapy (ECT) as an adjunctive treatment for a major depressive episode. The main purpose of the pilot study is to assess trial processes to help inform a future definitive trial.

Conditions

Interventions

DRUG

Ketamine

A sub-anaesthetic dose of ketamine will be administered in twice-weekly infusions

DRUG

Midazolam

A sub-anaesthetic dose of midazolam will be administered in twice-weekly infusions

Sponsors & Collaborators

  • St Patrick's Hospital, Ireland

    lead OTHER

Principal Investigators

  • Declan McLoughlin, PhD · St Patrick's Hospital

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-01-06
Primary Completion
2020-06-03
Completion
2020-06-03

Countries

  • Ireland

Study Locations

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Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04082858 on ClinicalTrials.gov