Protein-rich Nutritional Therapy Combined With Time-efficient Exercise in Cancer Therapy

Summary

This study aims to evaluate the effects of a 12-week protein-rich individualized nutritional therapy combined with different time-efficient exercise programs on overall physical fitness (cardiorespiratory fitness and muscular fitness), inflammation, and muscle mass/body composition in patients with malignant disease undergoing curative or palliative anti-cancer treatment

Conditions

• Cancer
• Cancer Cachexia
• Inflammation

Interventions

OTHER

Resistance Training

Conventional Resistance Training: Nutritional therapy (individualized, protein-rich nutritional therapy and counseling; targeted protein intake/day: 1.2 - 1.5 g per kg bodyweight) during a study period of 12 weeks combined with a resistance training program consisting of five exercises: exercises (chest, upper/lower back, abdominals, legs) * 1 set per exercise * time-effort per session: \~20 min * 2 training sessions per week

OTHER

WB-EMS

Whole-Body Electromyostimulation (WB-EMS): Nutritional therapy (individualized, protein-rich nutritional therapy and counseling; targeted protein intake/day: 1.2 - 1.5 g per kg bodyweight) during a study period of 12 weeks combined with WB-EMS training: * Stimulation protocol: Frequency of 85 Hz, pulse duration of 0.35 ms, stimulation period of 6 sec, resting period of 4 sec; patients perform simple exercises during the stimulation period following a video tutorial * time-effort per session: \~20 min * 2 training sessions per week

OTHER

High-intensity interval training (HIIT)

HIIT: Nutritional therapy (individualized, protein-rich nutritional therapy and counseling; targeted protein intake/day: 1.2 - 1.5 g per kg bodyweight) during a study period of 12 weeks combined with high-intensity interval training (HIIT): * supervised cycle-ergometer training at at 80-95% HRmax * time-effort per session: \~15 min * 2 training sessions per week

OTHER

Combined HIIT and Resistance Training (Combi)

HIIT combined with conventional Resistance Training: Nutritional therapy (individualized, protein-rich nutritional therapy and counseling; targeted protein intake/day: 1.2 - 1.5 g per kg bodyweight) during a study period of 12 weeks combined with a combined HIIT and resistance training program: HIIT: * supervised cycle-ergometer training at at 80-95% HRmax * time-effort per session: \~15 min * 1 training session per week Resistance Training: * five exercises: exercises (chest, upper/lower back, abdominals, legs) * 1 set per exercise * time-effort per session: \~20 min * 1 training session per week

Sponsors & Collaborators

• University of Erlangen-Nürnberg Medical School

  lead OTHER

Principal Investigators

• Dejan Reljic, Dr. · University Erlangen Nuremberg Medical School

• Yurdagül Zopf, Prof. · University Erlangen Nuremberg Medical School

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-05-01

Primary Completion

2022-03-31

Completion

2022-03-31

Countries

• Germany

Study Locations