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Influence of Reward and Punishment on Goal-directed and Habit Learning in Adolescent Anorexia Nervosa

NCT04051879 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 78

Last updated 2026-05-11

No results posted yet for this study

Summary

The proposed study of adolescents with anorexia nervosa (AN) will examine the association of behavioral differences in constructs of decision making, brain structure and connectivity, and eating disorder (ED) symptoms. This study tests the novel hypothesis that goal-directed and habit learning for reward and punishment is altered in AN and is uniquely associated with divergent symptoms and differences in corticostriatal connectivity and microstructural integrity. We will recruit 78 females currently ill with AN and 26 controls ages 13-17 to investigate how goal-directed and habit learning for reward and punishment correspond to 1) clinical symptoms collected via interviews, self-report assessments, and ecological momentary assessment (EMA), and 2) brain structure and connectivity in the resting state. Data collection will rely on a technology called functional magnetic resonance imaging (fMRI).

Conditions

  • Anorexia Nervosa

Sponsors & Collaborators

Principal Investigators

  • Christina Wierenga, PhD · University of California, San Diego

Eligibility

Min Age
13 Years
Max Age
17 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-04-01
Primary Completion
2025-03-24
Completion
2026-05-08

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04051879 on ClinicalTrials.gov