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Skeletal Muscle Protein Synthesis: Traditional and Cluster Sets

NCT04028726 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 8

Last updated 2019-07-24

No results posted yet for this study

Summary

Traditionally, when performing resistance exercise, repetitions are performed in a continuous manner resulting in a decrease in velocity, and thus power output. "Cluster" set is an alternative to counter the reduction in velocity and power output. Cluster sets incorporate a brief rest (15-30 seconds) between individual repetitions (inter-repetition rest) or group of repetitions (intra-set rest) within a set of resistive exercise. In contrast to traditional set configurations, which result in an almost linear decrease in force, velocity, and power -cluster sets maintain and/or attenuate the loss in power, primarily due to higher velocities.

The purpose of this research is to compare the muscle protein synthesis response to acute bouts of cluster and traditional set configurations. Investigators will assess muscle protein synthesis rates before and after acute resistance exercise in 14 resistance-trained males and females (Age: 20-35; back squat 1.5 x body weight; 3 years of resistance training experience). The volunteers are required to be removed (at least six weeks) from all ergogenic levels of nutritional supplements that have previously been shown to affect protein synthesis. Blood and muscle biopsies will be collected as a part of testing. Further, subjects will be required to perform moderate-to-high intensity resistance exercise.

Conditions

  • Resistance Exercise

Interventions

OTHER

Back-squat exercise

Participants begin with a 5 min dynamic warm-up. Then, they will perform two sets of five repetitions at 40-60% of predetermined 1-repetition maximum (1-RM). The clustered bout will be 4 sets of 2 clusters of 5 repetitions with a 30-second intra-set rest between clusters, and 90-second inter-set rest at a load 70% of 1-RM. The traditional bout will be 4 sets of 10 repetitions with a 120-second inter-set rest at a load 70% of 1-RM.

Sponsors & Collaborators

  • Texas Christian University

    collaborator OTHER

  • University of Illinois at Urbana-Champaign

    lead OTHER

Principal Investigators

  • Nicholas Burd, PhD · University of Illinois at Urbana-Champaign

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
20 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-08-25
Primary Completion
2018-10-25
Completion
2019-07-15

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04028726 on ClinicalTrials.gov