Screening of Gastric Cancer Via Breath Volatile Organic Compounds by Hybrid Sensing Approach

Summary

The study is aimed to determine the potential of volatile marker testing for gastric cancer screening.

The study will be addressing the role of confounding factors, including lifestyle factors, diet, smoking as well as addressing the potential role of microbiota in the composition of exhaled volatile markers.

Conditions

• Gastric Cancer
• Atrophic Gastritis
• Gastric Dysplasia
• H.Pylori Infection

Interventions

DEVICE

Breath sampling for VOC detection

Breath sampling will be performed by using a special sensor device and or GC-MS analysis (by collecting breath samples in adsorbent tubes). Pepsinogen testing will be used in a subgroup to identify serological increased risk for atrophy

PROCEDURE

Surgery material collection for VOC headspace analysis

Only for gastric cancer patients undergoing surgery (Group 1)

DIAGNOSTIC_TEST

Upper endoscopy

Routine endoscopic evaluation with a standard biopsy work-up according to updated Sydney system. Additional gastric contents for GC-MS and microbiota analysis in a subgroup. Endoscopy will be used only according to the clinical indications (in Group 4 - according to the results of pepsinogen tests)

DIAGNOSTIC_TEST

Microbiota testing

Faecal and gastric contents and biopsy samples for microbiota testing

Sponsors & Collaborators

• Technion, Israel Institute of Technology

  collaborator OTHER

• University of Ulm

  collaborator OTHER

• Uppsala University

  collaborator OTHER

• JLM Innovation GmbH

  collaborator UNKNOWN

• Universitaet Innsbruck

  collaborator OTHER

• Hospital Universitario San Ignacio

  collaborator OTHER

• Universidad de Pamplona

  collaborator OTHER

• Pontificia Universidad Catolica de Chile

  collaborator OTHER

• AC Camargo Cancer Center

  collaborator OTHER

• National Cancer Institute of Ukraine

  collaborator OTHER

• VTT Technical Research Centre of Finland

  collaborator OTHER

• University of Latvia

  lead OTHER

Principal Investigators

• Hossam Haick, PhD · TECHNION, Israel Institute for Technology

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-11-01

Primary Completion

2022-12-31

Completion

2026-12-31

Countries

• Brazil
• Chile
• Colombia
• Latvia
• Ukraine

Study Locations