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Adjuvant Radiotherapy on Circulating Cells in Breast Cancer Patients

NCT04002570 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 13

Last updated 2021-04-27

No results posted yet for this study

Summary

Radiation applied to the preserved breast during radiotherapy treatment activates numerous molecular cascades in tumor bed adjacent cells causing an inflammatory state. During this process, pre-clinical studies demonstrated CD11b + and CD11b+cKit+cells mobilization in the blood. These cells are involved in numerous processes during tumor progression/control and metastases development. The expected results in clinical setting allow us to investigate the development of innovative therapeutic and monitoring strategies. The clinical repercussions would consist in identifying new predictive and prognostic targets in breast cancer.

Conditions

Interventions

OTHER

blood samples collection

blood samples collection are performed at 4 different timepoints: preop, pre rt, week 6 rt, week 12-14 (fu) for GROUP I and GROUP II; blood samples collection are performed at 3 different timepoints: pre rt, week 6 rt, week 12-14 (fu) for GROUP I bis; blood samples collection are performed just once for control GROUP.

Sponsors & Collaborators

  • Curzio Rüegg, MD, Head of Department, University of Fribourg

    collaborator UNKNOWN

  • Swiss National Science Foundation

    collaborator OTHER

  • Tsoutsou Pelagia MD, Head of Radation Therapy Department

    collaborator UNKNOWN

  • Clinica Luganese Moncucco

    lead OTHER

Principal Investigators

  • Alessandra Franzetti Pellanda, MD · Clinica Luganese Moncucco

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-10-25
Primary Completion
2020-09-15
Completion
2020-12-30

Countries

  • Switzerland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04002570 on ClinicalTrials.gov