Use of DNAse in Neutrophilic Asthma
NCT03994380 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 19
Last updated 2026-04-20
Summary
In this pilot protocol, the researchers look to determine benefits from use of nebulized rh-DNase for 4 weeks in patients with neutrophilic asthma.
Conditions
- Neutrophilic Asthma
Interventions
- DRUG
-
RhDNAse Inhalation Solution
rhDNAse 2.5 mg nebulizer daily for 4 weeks
Sponsors & Collaborators
-
National Jewish Health
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-02-12
- Primary Completion
- 2022-05-31
- Completion
- 2022-12-31
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Study to Examine the Cytokine Levels, Gene Expression and Safety of a Single Nasal Dose of JNJ-43260295, in Healthy Participants, and Atopic Participants With Mild to Mild-Persistent Asthma
NCT02243189 ·Status: TERMINATED ·Phase: PHASE1
-
Study Evaluating the Safety and Effects of MN-221 in Subjects With Moderate to Severe Asthma
NCT00679263 ·Status: COMPLETED ·Phase: PHASE2
-
Change of Airway Hyperresponsiveness to Mannitol and Methacholine in Patients With Asthma
NCT01725360 ·Status: COMPLETED ·Phase: PHASE4
-
Study to Evaluate the Effect of Omalizumab on Improving the Tolerability of Specific Immunotherapy in Patients With Persistent Allergic Asthma
NCT00267202 ·Status: COMPLETED ·Phase: PHASE4
-
The Effect of Omalizumab on Airway Responsiveness to Adenosine in Patients With Poorly Controlled Asthma
NCT00133042 ·Status: COMPLETED ·Phase: PHASE4
-
Safety Study of Nebulized RNS60 to Treat Asthma.
NCT01057498 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, Tolerability, and Pharmacokinetics After a Single Dose of Orally Inhaled DNAzyme Solution for Nebulisation in Male Patients With Asthma
NCT01577953 ·Status: COMPLETED ·Phase: PHASE1
-
Alendronate to Prevent Loss of Bronchoprotection in Asthma
NCT02230332 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Investigation of Intravenous (IV) Administration of an Approved Drug (MK-0476, Montelukast Sodium) for Acute Asthma (MK-0476-288)
NCT00092989 ·Status: COMPLETED ·Phase: PHASE3
-
Study of Pulmozyme to Treat Severe Asthma Episodes
NCT00169962 ·Status: COMPLETED ·Phase: PHASE2
-
Phase II Efficacy Study of Aerosolized Recombinant Human IL-4 Receptor in Asthma
NCT00001909 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Reslizumab in Participants With Uncontrolled Asthma and Elevated Blood Eosinophils
NCT02452190 ·Status: COMPLETED ·Phase: PHASE3
-
Single Oral Dose of Dexamethasone Versus Five Days of Prednisone in Adult Asthma
NCT01241006 ·Status: COMPLETED ·Phase: PHASE4
-
A Study on the Effects of a Single Dose of Prednisone on Biomarkers of Allergen Responses in Asthmatics (MK-0000-175)
NCT01193049 ·Status: COMPLETED ·Phase: PHASE1
-
Symptom Clusters in Children With Exacerbation-prone Asthma
NCT04002362 ·Status: COMPLETED ·Phase: PHASE2
-
Safety and Efficacy of QAW039 in Sputum Eosinophilia and Persistent Asthma
NCT01545726 ·Status: COMPLETED ·Phase: PHASE2
-
Nasal Inflammation Following Endotoxin Challenge in Patients With Asthma
NCT06270576 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
Non-invasive Ways to Evaluate Lung Disease After Treatment With Xolair
NCT00139152 ·Status: COMPLETED ·Phase: PHASE4
-
A Study to Evaluate the Effect of a Single-Dose Intravenous Administration of MEDI-528
NCT00483041 ·Status: TERMINATED ·Phase: PHASE2
-
A Description of Inflammatory Cell Types In Moderate to Severe Pediatric Asthma: Eosinophilic and Non Eosinophilic Sputum Markers While on Anti-IgE Therapy
NCT00283504 ·Status: COMPLETED ·Phase: PHASE4
-
Effectiveness of the Aeroneb in Acute Severe Asthma
NCT03029156 ·Status: COMPLETED ·Phase: NA
-
A Single Ascending Dose Study in Healthy Participants and Multiple Ascending Dose Study of CNTO 7160 in Participants With Asthma and Participants With Atopic Dermatitis
NCT02345928 ·Status: COMPLETED ·Phase: PHASE1
-
Efficacy/Safety Study of Nebulized IVX-0142, a Novel Antiallergic Drug, in Mild Allergic Asthma
NCT00232999 ·Status: COMPLETED ·Phase: PHASE2
-
Open-Label Trial of the Use of Minocycline in the Treatment of Asthma
NCT00536042 ·Status: COMPLETED ·Phase: PHASE2
-
Safety Study of Zileuton Injection in Patients With Asthma
NCT00299065 ·Status: COMPLETED ·Phase: PHASE1/PHASE2