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Intraoperative Protective Mechanical Ventilation in Patients Requiring Emergency Abdominal Surgery

NCT03987789 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 707

Last updated 2026-04-21

No results posted yet for this study

Summary

The aim of this study is to compare the effects of a strategy aimed at increasing alveolar recruitment (high PEEP levels adjusted according to driving pressure and recruitment maneuvers) with that of a strategy aimed at minimizing alveolar distension (low PEEP level without recruitment maneuver) on postoperative respiratory failure and mortality in patients receiving low VT ventilation during emergency abdominal surgery.

Conditions

  • Emergency Abdominal Surgery
  • Mechanical Ventilation
  • General Anesthesia
  • Postoperative Morbidity

Interventions

OTHER

Driving-pressure-guided group

Patients will receive PEEP levels individually set at the highest possible value (up to 15 cmH2O) providing a driving pressure (airway plateau pressure minus PEEP) lower than 13 cmH2O, in addition to recruitment maneuvers.

OTHER

Low PEEP

Patients will receive a PEEP level ≤5 cmH2O without recruitment maneuvers

Sponsors & Collaborators

  • University Hospital, Clermont-Ferrand

    lead OTHER

Principal Investigators

  • Emmanuel Futier · CHU de Clermont-Ferrand

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-02-18
Primary Completion
2022-07-29
Completion
2022-10-27

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03987789 on ClinicalTrials.gov