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Effect of Hyperbaric Oxygen Therapy on Microcirculation

NCT03980210 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2026-01-08

No results posted yet for this study

Summary

Previous studies shoes that hyperoxia alters microcirculation.The investigators hypothesize that hyperbaric may restore microcirculation integrity. This hypothesis is supported by a recent study in rabbits, but no data exists for humans.

The study will expose fifteen healthy volunteers to a succession of different fraction of inspired oxygen and barometric pressure and assess microcirculatory and macrocirculatory changes via sidestream dark field videomicroscopy, near-infrared spectroscopy, Laser Doppler, transthoracic echocardiography and bio-impedancemetry at every step.

Conditions

  • Hyperbaric Oxygen Therapy

Interventions

PROCEDURE

Hyperbaric oxygen therapy

1. FiO2 0.21 - 1 ATA 2. FiO2 1 - 1 ATA 3. FiO2 1 - 2.5 ATA 4. FiO2 0.21 - 2.5 ATA 5. FiO2 0.21 - 1 ATA

Sponsors & Collaborators

  • University Hospital, Lille

    lead OTHER

Principal Investigators

  • Thibault Duburcq, MD · University Hospital, Lille

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
64 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-06-14
Primary Completion
2019-07-25
Completion
2019-07-25

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03980210 on ClinicalTrials.gov