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Effect of Hyperoxemia on Platelet Function in Healthy Volunteers

NCT01057420 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2010-08-24

No results posted yet for this study

Summary

Prospective, controlled, randomized crossover volunteer study to investigate the effect of hyperoxemia due to inhalation of oxygen (80% inspiratory fraction) via reservoir-face-mask on blood coagulation, especially platelet function, as measured by thrombelastography. According to results of basic animal and in vitro investigations, hyperoxemia may activate platelets by means of reactive oxygen species. This study aims at investigating a possible pro-coagulant effect of hyperoxemia in healthy volunteers. Additional studies on possible mechanisms are integrated.

* Trial with medical device

Conditions

  • Healthy Volunteers

Interventions

DRUG

oxygen inhalation

Inhalation of 80% oxygen via face mask

Sponsors & Collaborators

  • University of Zurich

    lead OTHER

Principal Investigators

  • Johannes Wacker, MD · Surgical Intensive Care Medicine, UniversitaetsSpital Zuerich

  • Reto Stocker, Prof., MD · Surgical Intensive Care Medicine, UniversitaetsSpital Zurich

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
25 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-04-30
Primary Completion
2010-03-31
Completion
2010-05-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01057420 on ClinicalTrials.gov