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Histological and Molecular Mechanisms of Pain in Patient With Chronic Pain From Adhesions

NCT03938168 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 61

Last updated 2024-12-31

No results posted yet for this study

Summary

11-20% of patients undergoing abdominal surgery develop chronic abdominal pain. Adhesions are a common cause of chronic pain following surgery. Adhesions develop after up to 90% of laparotomies and 70% of laparoscopic surgeries. Obviously, not all adhesions cause pain. It is still poorly understood why adhesions cause pain in some patients, while other patients with adhesions experience no pain.

In this study we explore possible mechanism through which adhesions might cause pain. For this purpose we will assess expression of molecular mediators (such as TRPV-1, SP, and the neurokinin receptor), histological characteristics, and fecal microbioma that might be associated with pain.Expression of these factor will be compared to sample from 30 patients with chronic pain attributed to adhesions, and 30 patients undergoing a reoperation with adhsiolysis for reasons unrelated to pain.

Conditions

Interventions

DIAGNOSTIC_TEST

Biopsy, fecal sample

Preoperatively and at 12 months after surgery, patients will obtain a fecal stool sample for microbioma analysis. Adhesions that are cut and released to acquire access to the operative field are stored for molecular and histological analyses.

Sponsors & Collaborators

  • Maastricht University Medical Center

    collaborator OTHER

  • Maas Hospital Pantein

    collaborator OTHER

  • Radboud University Medical Center

    lead OTHER

Principal Investigators

  • Richard P ten Broek, MD, PhD · Radboud University Medical Center

  • Harry van Goor, MD, PhD · Radboud University Medical Center

  • Richard P ten Broek, MD, PhD · Radboud University Medical Center

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-04-09
Primary Completion
2023-12-31
Completion
2024-12-20

Countries

  • Netherlands

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03938168 on ClinicalTrials.gov