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Re-Evaluation of the Effects of High PEEP During General Anesthesia For Surgery (REPEAT)

NCT03937375 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 3837

Last updated 2024-01-10

No results posted yet for this study

Summary

Aiming to understand the isolated impact of high PEEP in patients undergoing mechanical ventilation for general anesthesia for surgery, three appropriately sized international multicentre randomized controlled trials have been performed over recent years: the 'PROtective Ventilation using HIgh versus LOw PEEP trial (PROVHILO), the 'individualized PeRioperative Open-lung Ventilation trial' (iPROVE), and the 'Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients trial' (PROBESE). These three trials had several similarities in key areas of their study protocols, inclusion and exclusion criteria, and collected data, and even the primary and secondary outcomes. Of note, the three trials combined high PEEP with recruitment manoeuvres. This allows an individual patient data meta-analysis.

Conditions

  • Surgery
  • Mechanical Ventilation Complication
  • Pulmonary Complication

Interventions

BEHAVIORAL

High PEEP

Use of high levels of PEEP combined with recruitment maneuvers and low tidal volume ventilation during general anesthesia

BEHAVIORAL

Low PEEP

Use of low levels of PEEP without recruitment maneuvers and low tidal volume ventilation during general anesthesia

Sponsors & Collaborators

  • Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

    collaborator OTHER

  • University Hospital Carl Gustav Carus

    collaborator OTHER

  • Hospital Clínico Universitario de Valencia

    collaborator OTHER

  • Hospital Israelita Albert Einstein

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-01-01
Primary Completion
2019-12-01
Completion
2020-01-30

Countries

  • Germany
  • Netherlands
  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03937375 on ClinicalTrials.gov