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Ventilation Strategy During General Anesthesia for Orthopedic Surgery: A Quality Improvement Project

NCT03657368 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 2860

Last updated 2025-08-27

Study results available
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Summary

The objective is to determine the optimal intraoperative ventilation strategy among the chosen tidal volume and positive end-expiratory pressure (PEEP) levels, and standardize it in an enhanced recovery pathway for orthopedic surgical patients. In particular, we propose to determine which combination of intraoperative tidal volume and positive end-expiratory pressure is best for patients having elective orthopedic surgery.

Conditions

  • Orthopedic Surgery
  • Ventilation

Interventions

PROCEDURE

Low tidal Volume

Tidal volume = 6 ml/kg predicted body weight

PROCEDURE

High tidal Volume

Tidal volume = 10 ml/kg predicted body weight

PROCEDURE

Low PEEP

PEEP = 5 cm H2O

PROCEDURE

High PEEP

PEEP = 8 cm H2O

Sponsors & Collaborators

  • The Cleveland Clinic

    lead OTHER

Principal Investigators

  • Alparslan Turan, MD · The Cleveland Clinic

Study Design

Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-09-03
Primary Completion
2020-10-23
Completion
2020-10-23

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03657368 on ClinicalTrials.gov