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Dose-effect Relationship Between microRNAs in Peripheral Blood and Radiation Injury

NCT03928782 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 8

Last updated 2019-04-26

No results posted yet for this study

Summary

Rapid and accurate assessment of radiation injury dose is the key to success in early treatment and an urgent issue to be solved in clinical medicine.Researches showed that the expression of the microRNAs in human peripheral blood had much correlation with radiation injury resulted from different dosages of radiation.In this study,acute leukemic patients who will be pretreated by whole-body radiation are taked as the object of study,and biochip technology are adopted to detect the expression levels of the microRNAs in subject peripheral blood before-and-after radiation,and different expression is tested and Bioinformatics prediction,to evaluate the correlation between radiation injury dose and expression levels of the microRNAs in human peripheral blood.

Conditions

  • Radiation Injuries, Experimental

Interventions

RADIATION

5 Gy or 10 Gy units of whole-body radiation

8 subjects will be received 5 Gy units of whole-body radiation or 10 Gy units of whole-body radiation.

Sponsors & Collaborators

  • Affiliated Hospital to Academy of Military Medical Sciences

    lead OTHER

Principal Investigators

  • Lu rongjian, doctor · Chinese PLA 307 Hospital

  • Guo biao, master · Chinese PLA 307 Hospital

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-12-01
Primary Completion
2019-07-01
Completion
2019-09-01

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03928782 on ClinicalTrials.gov