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Dental Plaque Microbiota in Caries-free and Caries-active Children

NCT03906981 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2019-09-25

No results posted yet for this study

Summary

Dental caries is a polymicrobial infection originally thought to be caused by Streptococcus mutans and Lactobacilli. However, unprecedented developments in modern molecular techniques have demonstrated that several microbial species are associated with the disease in addition to streptococci and lactobacilli. Dental caries initiation and progression is a dynamic process in which demineralization of the tooth structure, as a result of acid production from acidogenic bacteria (due to carbohydrate metabolism) is being counteracted by the remineralization of the tooth surface by strong alkali production by certain bacteria in the dental biofilm. The aim of the present study is to identify the different microbiota in the oral biofilm using new laboratory techniques as well as the levels of salivary proteins in caries-free compared with caries active Arab children.

Conditions

  • Caries
  • Plaque

Interventions

OTHER

Plaque from each subject will be collected but there will be no intervention

No intervention

Sponsors & Collaborators

  • Kuwait University

    lead OTHER

Principal Investigators

  • Muawia A Qudeimat, MDentSci · Kuwait University

Eligibility

Min Age
6 Years
Max Age
9 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-01-01
Primary Completion
2019-03-01
Completion
2019-04-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03906981 on ClinicalTrials.gov