A Pragmatic Trial of Two Strategies for Implementing an Effective eHealth HIV Prevention Program (Keep It Up! 3.0)

Summary

This study evaluates and compares two implementation strategies of an online HIV prevention intervention: Strategy 1 in which community-based organizations apply, and are selected, for funding to deliver Keep It Up! through current HIV testing programs; and Strategy 2 which is a "direct-to-consumer" model where centralized staff at Northwestern University recruit participants nationally through online advertising campaigns and manage engagement.

Conditions

• HIV/AIDS
• Gonorrhea
• Chlamydia

Interventions

BEHAVIORAL

Keep It Up! 3.0

KIU! is an online HIV prevention intervention developed for high-risk young men who have sex with men (YMSM) who recently tested HIV negative. Content was developed in collaboration with YMSM-serving CBOs and subjected to usability testing with diverse YMSM. The Information-Motivation-Behavioral Skills model and eLearning principles guided development of highly interactive, engaging, and culturally relevant health messages. KIU! involves 7 modules completed across 3 sessions, totaling \~1 hour of main content, plus 2 booster sessions at 6- and 12-week follow-ups. Each module is based on a setting or situation relevant to YMSM (e.g., connecting to the gay community and meeting guys through apps), with developmentally appropriate behavior change content embedded. KIU! uses diverse delivery methods (e.g. videos, animation, games) to address HIV knowledge gaps, motivate safer behaviors, teach behavioral skills, and instill self-efficacy for preventive behaviors.

Sponsors & Collaborators

• National Institute of Mental Health (NIMH)

  collaborator NIH

• Boston Medical Center

  collaborator OTHER

• Weill Medical College of Cornell University

  collaborator OTHER

• Marquette University

  collaborator OTHER

• Northwestern University

  lead OTHER

Principal Investigators

• Brian Mustanski, PhD · Northwestern University

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

34 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-10-09

Primary Completion

2023-03-31

Completion

2023-03-31

Countries

• United States

Study Locations