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The Functional Neuroanatomy of the Human Physiological Stress Response

NCT03867344 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 74

Last updated 2026-01-05

No results posted yet for this study

Summary

The purpose of this study is to examine the effect of a moderately low blood sugar stress on the nervous system. The investigators hope that information obtained from completing this study will help to reveal information about how a non-psychological stress impacts the parts of the brain that react to stress and the autonomic nervous system. The autonomic nervous system is the part of the nervous system that provides the body with involuntary or automatic control of heart rate, blood pressure, and breathing.

Conditions

Interventions

OTHER

Hypoglycemic Hyperinsulinemic Clamp

Participants undergo a 120-minute hypoglycemic hyperinsulinemic clamp procedure.

OTHER

Normoglycemic Hyperinsulinemic Clamp

Participants undergo a 120-minute normoglycemic hyperinsulinemic clamp procedure.

Sponsors & Collaborators

Principal Investigators

  • Roy Freeman, MD · Beth Israel Deaconess Medical Center

  • Gail K Adler, MD, PhD · Brigham and Women's Hospital

  • David Borsook, MD, PhD · Boston Children's Hospital

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-10-01
Primary Completion
2025-12-30
Completion
2025-12-30

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03867344 on ClinicalTrials.gov