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A Pathophysiological Study of the Postprandial Human Liver (PLS)

NCT03849235 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 87

Last updated 2026-07-06

No results posted yet for this study

Summary

Fatty liver disease is a globally widespread disease. The identification of valid biomarkers and targets for potential treatments requires in-depth knowledge about the pathophysiology of the postprandial liver. The study will consist of seven work packages (WP) including blood tests and liver biopsies taken after fasting or ingestion of a standardized meal in: healthy controls (WP 1), patients with NAFLD (WP 2), and patients with cirrhosis (WP 3) ; before and after a standardised meal in healthy controls (WP 4), and before and after glucagon in healthy controls (WP5), patients with NAFLD (WP6), and patients with T2DM and NAFLD (WP7).

Conditions

Interventions

DIETARY_SUPPLEMENT

Standardised meal

Standardised meal (Nutridrink, Nutricia, 300 kcal, 18.4 g carbohydrates, 5.8 g fat, 12 g protein).

DRUG

Glucagon bolus

Intravenous bolus of 0.2 mg glucagon

Sponsors & Collaborators

  • University of Copenhagen

    collaborator OTHER

  • Copenhagen University Hospital, Hvidovre

    lead OTHER

Principal Investigators

  • Nicolai Jacob Wewer Albrechtsen, MD, Assoc. Prof. · NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark

  • Lise Lotte Gluud, MD, Prof · Gastrounit, Copenhagen University Hospital Hvidovre, Denmark

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-03-02
Primary Completion
2025-08-21
Completion
2025-09-01

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03849235 on ClinicalTrials.gov