MedTrace Logo

Neo-RT: A Study Investigating Whether Changing the Sequence of Treatments (Starting Radiotherapy Followed by Hormone Therapy Before Surgery) is Feasible

NCT03818100 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 43

Last updated 2021-07-27

No results posted yet for this study

Summary

Four in 10 women diagnosed with breast cancer undergo mastectomy with or without breast reconstruction and less than half are satisfied with how they look unclothed. Breast conservation (removing the area with the lump only) can offer less extensive surgery and improved breast appearance, which can therefore increase well-being.

Intensity-modulated radiotherapy (IMRT) closely shapes the radiation beam to the cancer and is currently given after breast surgery. A new combination of IMRT followed by hormone treatment given before surgery, may increase the possibility of breast conservation.

Conditions

Interventions

RADIATION

Intensity modulated radiotherapy (IMRT)

Simultaneous integrated boost technique using IMRT: 48 Gray (Gy) and 40 Gy will treat tumour and breast tissue respectively, in 15 fractions over 3 weeks.

DRUG

Endocrine therapy

Endocrine therapy will commence following completion of radiotherapy, and will continue for 20 weeks.

PROCEDURE

Breast conserving surgery

Surgery carried out using local protocol following completion of endocrine therapy.

Sponsors & Collaborators

  • Breast Cancer Now

    collaborator OTHER

  • CRUK Cambridge Institute

    collaborator UNKNOWN

  • CCTU- Cancer Theme

    lead OTHER

Principal Investigators

  • Charlotte E Coles, MB ChB, MRCP, FRCR, PhD · University of Cambridge

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-03-26
Primary Completion
2022-04-30
Completion
2022-12-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03818100 on ClinicalTrials.gov