Study of a Shortened Radiation Therapy Schedule in People With Breast Cancer
NCT04648904 · Status: ACTIVE_NOT_RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 71
Last updated 2025-05-22
Summary
The purpose of this study is to see whether providing radiation on a shortened (compressed) schedule of 5 days in a row is a safe and effective approach to prevent cancer from coming back in people who have had a mastectomy.
Conditions
- Invasive Breast Cancer
- Post-mastectomy
Interventions
- RADIATION
-
Radiotherapy
A total dose of 26 Gy in 5 fractions will be given once daily over 5 consecutive weekdays (or within 10 consecutive weekday to allow for treatment delays, interruptions, logistical problems, scheduling issues and weekends/holidays).
Sponsors & Collaborators
-
Memorial Sloan Kettering Cancer Center
lead OTHER
Principal Investigators
-
Aftif Khan, MD · Memorial Sloan Kettering Cancer Center
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 30 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-11-24
- Primary Completion
- 2026-11-30
- Completion
- 2026-11-30
Countries
- United States
Study Locations
More Related Trials
-
Accelerated Intensity Modulated Radiation Therapy (AIMRT) to the Breast After Segmental Mastectomy
NCT02606708 ·Status: COMPLETED ·Phase: NA
-
Radiation Therapy After Lumpectomy in Treating Women With Ductal Carcinoma in Situ or Invasive Breast Cancer
NCT00054301 ·Status: COMPLETED ·Phase: PHASE2
-
The Postoperative Radiotherapy in N1 Breast Cancer Patients
NCT05440149 ·Status: RECRUITING ·Phase: PHASE3
-
Phase III Study of 5tx vs 15tx of RT (X-rays or Protons) Including RNI in Breast Cancer Patients
NCT04443413 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Cosmetic Result/Toxicity in Post-Mastectomy Immediate Reconstruction Expander+RT
NCT01664091 ·Status: COMPLETED ·Phase: NA
-
Three Fraction Accelerated Partial Breast Irradiation as the Sole Method of Radiation Therapy for Low-risk Stage 0 and I Breast Carcinoma
NCT03612648 ·Status: COMPLETED ·Phase: NA
-
RCT Comparing 2 Radiotherapy HypoFractionation Schedules In Breast Cancer Patients
NCT04550910 ·Status: UNKNOWN ·Phase: NA
-
Hypo Versus Conventional Fractionation in Reconstructed-Breast Cancer Mastectomy Patients
NCT05253170 ·Status: NOT_YET_RECRUITING ·Phase: PHASE3
-
Accelerated Hypofractionated Radiotherapy (AHF-RT) for the Treatment of Breast Cancer
NCT01278212 ·Status: COMPLETED ·Phase: NA
-
Quadrant High Dose Rate Intraoperative Radiation Therapy (IORT) for Early-Stage Breast Cancer: A Pilot Study
NCT00595062 ·Status: COMPLETED ·Phase: NA
-
Phase II Study of Intra-Operative Electron Irradiation and External Beam Irradiation After Lumpectomy in Patients With T1N0M0 and T2N0M0 Breast Cancer
NCT01215162 ·Status: COMPLETED ·Phase: PHASE2
-
Radiation Therapy in Treating Women Undergoing Lumpectomy for Stage I or Stage IIA Breast Cancer
NCT00602108 ·Status: COMPLETED ·Phase: PHASE2
-
Hypofractionated Vs Conventional Fractionated Postmastectomy Radiotherapy for High Risk Breast Cancer
NCT03856372 ·Status: RECRUITING ·Phase: NA
-
Radiation Therapy in Treating Patients With Stage 0-II Breast Cancer
NCT01245712 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Delayed-Immediate Breast Reconstruction
NCT00473122 ·Status: COMPLETED ·Phase: PHASE2
-
Partial Breast Radiation Therapy in Treating Women Undergoing Breast Conservation Therapy for Early-Stage Breast Cancer
NCT00599989 ·Status: COMPLETED ·Phase: NA
-
Clinical Trial of The Use of Bolus in Post Mastectomy Irradiation in Breast Cancer
NCT01925651 ·Status: COMPLETED ·Phase: NA
-
Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer
NCT03414970 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Neo-RT: A Study Investigating Whether Changing the Sequence of Treatments (Starting Radiotherapy Followed by Hormone Therapy Before Surgery) is Feasible
NCT03818100 ·Status: UNKNOWN
-
Local and Regional Radiotherapy for Nipple Sparing Mastectomy With Implant
NCT05213962 ·Status: ENROLLING_BY_INVITATION
-
Breast Fractionation Study - Standard Versus Investigational Fractionation Trial - Nodal Radiation
NCT04909125 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Hypofractionated Radiation Therapy in Preventing Recurrence in Patients With Breast Cancer After Surgery
NCT03324802 ·Status: COMPLETED ·Phase: PHASE3
-
Accelerated Partial Breast Irradiation Versus Standard or Hypofractionated Whole-Breast Irradiation, in Early Breast Cancer, After Breast-conserving Surgery
NCT04669873 ·Status: RECRUITING ·Phase: NA
-
Radiation Therapy in Treating Women Who Have Undergone Breast Conservation Surgery and Systemic Therapy for Early Breast Cancer
NCT00818051 ·Status: UNKNOWN ·Phase: PHASE3
-
Prospective Outcomes After Reconstruction and Radiotherapy for Breast Cancer
NCT00845078 ·Status: WITHDRAWN