S9927 Radiation Therapy After Surgery, Chemotherapy, and/or Hormone Therapy in Stage II Breast Cancer

Summary

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known whether mastectomy, chemotherapy, and/or hormone therapy are more effective with or without radiation therapy in treating breast cancer.

PURPOSE: Randomized phase III trial to compare the effectiveness of mastectomy, chemotherapy, and/or hormone therapy with or without radiation therapy in treating women who have stage II breast cancer.

Conditions

• Breast Cancer

Interventions

RADIATION

radiation therapy

PROCEDURE

surgery

surgery

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• North Central Cancer Treatment Group

  collaborator NETWORK

• American College of Surgeons

  collaborator OTHER

• Eastern Cooperative Oncology Group

  collaborator NETWORK

• Radiation Therapy Oncology Group

  collaborator NETWORK

• Cancer and Leukemia Group B

  collaborator NETWORK

• NCIC Clinical Trials Group

  collaborator NETWORK

• NSABP Foundation Inc

  collaborator NETWORK

• SWOG Cancer Research Network

  lead NETWORK

Principal Investigators

• Lori J. Pierce, MD · University of Michigan Rogel Cancer Center

• Michael G. Haddock, MD · Mayo Clinic

• Stephen B. Edge, MD · Roswell Park Cancer Institute

• Eric A. Strom, MD, FACR · M.D. Anderson Cancer Center

• Lawrence J. Solin, MD, FACR · Abramson Cancer Center at Penn Medicine

• Lawrence B. Marks, MD · Duke University

• Timothy J. Whelan, MD · Margaret and Charles Juravinski Cancer Centre

• Melvin Deutsch, MD · UPMC Cancer Center at UPMC Presbyterian

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

21 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2000-06-30

Primary Completion

2005-03-31

Completion

2005-03-31

Countries

• Canada

Study Locations