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Involvement of SK3 Calcium Channel in Taxane Neuropathy

NCT03816904 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 97

Last updated 2021-04-28

No results posted yet for this study

Summary

Taxane neuropathy is a common and long-term side effect of long-term morbidity in patients surviving cancer. No preventive or symptomatic treatment has been shown to be effective. Its pathophysiology is poorly known and probably multifactorial. A possible mechanism would be mediated by the activation of the SK3 calcium channel: a retrospective study carried out at the University Hospital of Tours (Carina RUA) found a significant association between the number of CAG triplets in the KCNN3 gene coding for the SK3 channel and the appearance of a taxane neuropathy.

Conditions

Interventions

OTHER

Blood samples

Blood samples before the introduction of chemotherapy

Sponsors & Collaborators

  • University Hospital, Tours

    lead OTHER

Principal Investigators

  • Catherine BARBE, MD · University Hospital, Tours

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-02-06
Primary Completion
2020-06-12
Completion
2020-06-12

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03816904 on ClinicalTrials.gov