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An Imaging Framework for Clinically Testing New Treatments to Prevent Post-traumatic OA

NCT03809520 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 97

Last updated 2026-04-24

Study results available
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Summary

The immediate goal of the proposed research is to test the value of a new low-cost, low-dose standing CT system for efficient early detection of both joint degeneration and elevated contact stress. The standing CT scanner holds promise for detecting arthritic changes earlier than other imaging modalities because of the combination of its 3D nature and ability to image joints in a weight-bearing pose. A secondary goal of the proposed research is to enable predictive models for osteoarthritis risk based on measures of post treatment contact stress, both to inform treatment and so that new interventions can be tested in a manner incorporating risk stratification.

Conditions

  • Orthopedic Disorder
  • Trauma
  • Ankle Fractures
  • Post-traumatic Osteoarthritis

Interventions

RADIATION

pedCAT

Weight-bearing CT scan (pedCAT) of ankles to measure 3D joint space width following ankle fracture.

Sponsors & Collaborators

  • Orthopaedic Trauma Association

    collaborator OTHER

  • Arthritis Foundation

    collaborator OTHER

  • University of Washington

    collaborator OTHER

  • University of Utah

    collaborator OTHER

  • University of Kansas Medical Center

    collaborator OTHER

  • J L Marsh

    lead OTHER

Principal Investigators

  • J L Marsh, MD · University of Iowa

Study Design

Allocation
NA
Purpose
OTHER
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-02-01
Primary Completion
2022-03-31
Completion
2022-03-31
FDA Device
Yes

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03809520 on ClinicalTrials.gov