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Impact of Periodontal Treatment on the RANKL/OPG Ratio in Crevicular Fluid

NCT03787875 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2018-12-26

No results posted yet for this study

Summary

Objectives: Alveolar resorption is one of the most important events in periodontitis. Osteoclast activity is regulated by the ratio between receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG). The aim of this study was to evaluate changes in the RANKL/OPG ratio in crevicular fluid after periodontal treatment.

Material and methods: A total of 15 patients with periodontitis were included in the study group. Samples were collected from an area with active periodontitis and a healthy area. The RANKL and OPG levels were measured before and after periodontal scaling and root planing (SRP) treatment. The study group was compared to the control group, which included 10 patients without periodontitis.

Conditions

  • Periodontal Diseases
  • Biomarkers
  • Bone Resorption

Interventions

PROCEDURE

periodontal treatment

In the study group, periodontal scaling and root planning treatment of the 4 quadrants was performed for two consecutive weeks without the use of antiseptics or antibiotics, and the patients were instructed in oral hygiene, including both brushing techniques and proximal hygiene.

Sponsors & Collaborators

  • University of Valencia

    lead OTHER

Eligibility

Min Age
40 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-02-02
Primary Completion
2016-06-05
Completion
2016-11-06

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03787875 on ClinicalTrials.gov