Study of Different Therapeutic Strategies in Hydatidiform Mole With Lung Nodule

Summary

The purpose of present study is to provide clinical evidences for the appropriate management of molar pregnancy with lung nodule. The hydatidiform mole patients with lung nodule ≥1.0cm will be randomized into 2 groups: A. treated with chemotherapy immediately, B. follow up until hCG level met FIGO diagnostic criteria of GTN (B1) or hCG level declined to normal spontaneously (B2). Lung nodule \<1.0cm will directly treated as group C

Conditions

• Hydatidiform Mole
• Gestational Trophoblastic Neoplasia

Interventions

OTHER

Follow up

the follow up group would be naturely didived into 2 subgroups depending the hCG regression degree.

DRUG

chemotherapy

First line treatments：low risk：Methotrexate or ACTD; high risk：EMA-CO

Sponsors & Collaborators

• Qilu Hospital of Shandong University

  collaborator OTHER

• Tongji Hospital Affiliated to Tongji Medical College of HUST

  collaborator UNKNOWN

• The First People's Hospital of Yunnan

  collaborator OTHER

• Tianjin Central Hospital of Gynecology Obstetrics

  collaborator OTHER

• Women and Children's Hospital of Ningbo University

  collaborator UNKNOWN

• First Affiliated Hospital of Wenzhou Medical University

  collaborator OTHER

• Hangzhou Fuyang Women And Children Hospital

  collaborator UNKNOWN

• Zhejiang Provincial Tongde Hospital

  collaborator OTHER

• Shaoxing Shangyu Women And Children Hospital

  collaborator UNKNOWN

• Huzhou Maternity and Child Health Care Hospital

  collaborator UNKNOWN

• Women's Hospital School Of Medicine Zhejiang University

  lead OTHER

Principal Investigators

• Xing Xie · Women's Hospital, Zhejiang University School of Medicine

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Max Age

60 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-12-24

Primary Completion

2030-09-01

Completion

2030-09-01

Countries

• China

Study Locations