Study to Evaluate the Safety of Intravitreal APL-2 in Patients Diagnosed With Geographic Atrophy
NCT03777332 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 19
Last updated 2021-11-10
Summary
Safety Assessment of APL-2 in Patients with Geographic Atrophy
Conditions
Interventions
- DRUG
-
PEGCETACOPLAN (APL-2)
Complement (C3) Inhibitor
Sponsors & Collaborators
-
Apellis Pharmaceuticals, Inc.
lead INDUSTRY
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 60 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2018-11-05
- Primary Completion
- 2021-04-01
- Completion
- 2021-04-01
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Assessment of Safety, Tolerability and Pharmacokinetics of Intravitreal Pegcetacoplan (APL-2) for Patients With Wet AMD
NCT02461771 ·Status: COMPLETED ·Phase: PHASE1
-
Pegcetacoplan (APL-2) in Neovascular AMD
NCT03465709 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Clinical Study to Investigate Safety and Efficacy of GSK933776 in Adult Patients With Geographic Atrophy Secondary to Age-related Macular Degeneration
NCT01342926 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Safety, Tolerability, and Evidence of Activity of FCFD4514S Administered Monthly or Every Other Month to Patients With Geographic Atrophy
NCT01229215 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy
NCT06779773 ·Status: RECRUITING
-
A Phase 1/2 Study of the Safety and Efficacy of BRX011 Oral Administration Once Daily in Subjects With Geographic Atrophy Secondary to Age-Related Macular Degeneration
NCT07029945 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
Study of NGM621 in Participants With Geographic Atrophy
NCT04014777 ·Status: COMPLETED ·Phase: PHASE1
-
A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration
NCT06161584 ·Status: ACTIVE_NOT_RECRUITING
-
A Study of NGM621 in Participants With Geographic Atrophy
NCT04465955 ·Status: COMPLETED ·Phase: PHASE2
-
Intravitreal Aflibercept for Submacular Hemorrhage
NCT03169660 ·Status: COMPLETED ·Phase: PHASE4
-
A Safety and Efficacy Study of Brimonidine Intravitreal Implant in Geographic Atrophy Secondary to Age-related Macular Degeneration
NCT02087085 ·Status: TERMINATED ·Phase: PHASE2
-
Study to Evaluate a Pegcetacoplan (Syfovre®) Prefilled Syringe
NCT07214740 ·Status: COMPLETED ·Phase: PHASE3
-
Safety and Efficacy of Intravitreal LFG316 in Wet Age Related Macular Degeneration (AMD)
NCT01535950 ·Status: COMPLETED ·Phase: PHASE2
-
A Study Investigating the Safety and Efficacy of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
NCT02247531 ·Status: TERMINATED ·Phase: PHASE3
-
Avacincaptad Pegol Open-Label Extension for Patients With Geographic Atrophy
NCT05536297 ·Status: COMPLETED ·Phase: PHASE3
-
Intravitreal LFG316 in Patients With Advanced Age-related Macular Degeneration
NCT01255462 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Test Whether BI 771716 Helps People With an Advanced Form of Age-related Macular Degeneration (AMD) Called Geographic Atrophy
NCT06722157 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Intravitreal Injections of RO7303359 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
NCT04615325 ·Status: COMPLETED ·Phase: PHASE1
-
Efficacy and Safety of Two Different Aflibercept Regimens in Subjects With Neovascular Age-related Macular Degeneration (nAMD)
NCT02540954 ·Status: COMPLETED ·Phase: PHASE3
-
A Study Investigating the Efficacy and Safety of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
NCT02247479 ·Status: TERMINATED ·Phase: PHASE3
-
Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ACU-4429 in Subjects With Geographic Atrophy
NCT01002950 ·Status: COMPLETED ·Phase: PHASE2
-
Intravitreal (IVT) Pozelimab for Geographic Atrophy (GA) in Adult Participants
NCT07230834 ·Status: RECRUITING ·Phase: PHASE1
-
Study to Evaluate the Safety of CG-P5 Peptide Eye Drops in Patients Diagnosed With Age-related Wet Macular Degeneration
NCT06132035 ·Status: RECRUITING ·Phase: PHASE1
-
SAD of IVT VP-001 in PRPF31 Mutation-Associated Retinal Dystrophy Subjects
NCT05902962 ·Status: COMPLETED ·Phase: PHASE1
-
Structured Post-marketing Surveillance to Collect the Safety Data of Intravitreal Aflibercept Injection (IVT-AFL) in Patients of Wet Age-related Macular Degeneration During Real World Clinical Practice
NCT03290794 ·Status: COMPLETED