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Estimation of Sialic Acid and IL10 Levels in Stage 1 and 2 Periodontitis Patients

NCT03775967 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2019-11-26

No results posted yet for this study

Summary

Sialic acid (SA) is the generic term given to a family of acetylated derivatives of neuraminic acid. SA is a 9 carbon monosaccharide. An important function of host SA is to regulate innate immunity. SA is present in several acute phase proteins which are known to be associated with periodontitis. There exists a need for a biomarker, for early detection of disease evolution and more robust therapy efficacy measurements. Till date, there is very little data regarding simultaneous estimation and comparison of total SA content in saliva. IL-10, an anti-inflammatory cytokine, regulates the synthesis of pro-inflammatory cytokines such as IL-1, -2, -6 and stimulates protective antibody production. IL-10 is expressed in both healthy and diseased human periodontal tissues and is reported to be reduced in patients infected with Aggregatibacter actinomycetemcomitans.

The present study was therefore undertaken with an aim, to not only assess the levels of TSA(Total sialic acid levels),but also of IL 10 levels in saliva from stage 1(mild) to stage 2(moderate) periodontitis patients

Conditions

  • Periodontal Disease

Interventions

DIAGNOSTIC_TEST

sialic acid

sialic acid level estimation in salivary samples

DIAGNOSTIC_TEST

IL10

IL10 estimation in salivary samples

Sponsors & Collaborators

  • Ajman University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-10-10
Primary Completion
2019-01-10
Completion
2019-02-10

Countries

  • India

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03775967 on ClinicalTrials.gov