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KP-10 and Insulin Secretion in Men

NCT03771326 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 14

Last updated 2018-12-12

No results posted yet for this study

Summary

Induction of insulin secretion by kisspeptin is observed in mouse, pig, rat, and human islets in vitro and in rats, mice and monkeys in vivo, but its mechanism is not fully clear. The present study was designed to investigate the role of KP-10 on insulin secretion in adult healthy and obese men with insulin resistance. The aim of selection of obese persons for the present study was to investigate the effect of acute KP-10 administration in a metabolically challenged condition where the pancreatic beta cells are already highly activated. The long-term objective of this study was to understand the physiological role of kisspeptin signalling in the regulation of insulin secretion in human health and disease.

Conditions

  • Kisspeptin Action on Insulin in Healthy Normal Men
  • Kisspeptin Action on Insulin in Obese Diabetic Men

Interventions

BIOLOGICAL

Kisspeptin-10

Kisspeptin-10 (metastin 45-54, Calbiochem, Darmstadt, Germany)

Sponsors & Collaborators

  • Quaid-e-Azam University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-10-29
Primary Completion
2013-11-04
Completion
2014-01-10

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03771326 on ClinicalTrials.gov