TS Overexpression in SCLC: Mechanism and Therapeutic Targeting
NCT03741829 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 12
Last updated 2020-02-05
Summary
The purpose of this research study is to determine the amount of a protein named thymidine synthase that is being made by cancer and to develop laboratory models called PDX (patient derived xenografts) to learn more about SCLC (small cell lung cancer) and to begin testing new treatments.
Conditions
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH -
Wake Forest University Health Sciences
lead OTHER
Principal Investigators
-
William Gmeiner, Ph.D, MBA · Wake Forest University Health Sciences
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2017-06-14
- Primary Completion
- 2020-01-03
- Completion
- 2020-01-03
Countries
- United States
Study Locations
More Related Trials
-
A Phase 2, Open-label, Randomized, Multicenter Study of Tarlatamab Dosing Regimens in Subjects With SCLC
NCT06745323 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
R-(-)-Gossypol Acetic Acid in Treating Patients With Recurrent Extensive-Stage Small Cell Lung Cancer
NCT00773955 ·Status: COMPLETED ·Phase: PHASE2
-
HTMC0435 and Temozolomide in Treating Patients With Small Cell Lung Cancer
NCT05728619 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Paclitaxel in Treating Patients With Extensive-Stage Small Cell Lung Cancer
NCT00005646 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy, Radiation Therapy, and Gefitinib in Treating Patients With Stage III Non-Small Cell Lung Cancer
NCT00040794 ·Status: COMPLETED ·Phase: PHASE2
-
Molecular Signatures of Relapse in Tissue Samples From Patients With Small Cell Lung Cancer Who Are Receiving Cisplatin and Etoposide
NCT02250404 ·Status: WITHDRAWN
-
Bcl-2 Antisense Oligodeoxynucleotide G3139 and Paclitaxel in Treating Patients With Recurrent Small Cell Lung Cancer
NCT00005032 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Using Ex Vivo Tumoroids To Predict Immunotherapy Response In NSCLC
NCT05332925 ·Status: RECRUITING
-
Temsirolimus and Radiation for Non-Small Cell Lung Cancer
NCT00796796 ·Status: COMPLETED ·Phase: PHASE1
-
Study of the Efficacy of an Investigational Drug in Adult Patients With Non Small-Cell Lung Cancer (NSCLC)
NCT00034957 ·Status: COMPLETED ·Phase: PHASE2
-
Study of BMS-275183 in Patients With Pre-treated Non-small Cell Lung Cancer
NCT00099879 ·Status: TERMINATED ·Phase: PHASE2
-
Locally Advanced NSCLC Treated With Radiochemotherapy: Phase 2 Study on the Value of a Stereotactic Boost
NCT06627738 ·Status: RECRUITING ·Phase: PHASE2
-
Bioelectrical Impedance Phase Angle in Predicting Treatment Outcome in Patients With Extensive Stage Small Cell Lung Cancer Receiving First-Line Chemotherapy
NCT02011087 ·Status: TERMINATED ·Phase: NA
-
Combination Chemotherapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer
NCT00025272 ·Status: COMPLETED ·Phase: PHASE2
-
Bronchoscopic Intratumoral Chemotherapy for Small Cell Lung Cancer (SCLC)
NCT01487499 ·Status: TERMINATED ·Phase: PHASE3
-
Chemotherapy in Treating Patients With Lung Cancer
NCT01067794 ·Status: COMPLETED
-
CCI-779 in Treating Patients With Stage IIIB (With Pleural Effusion) or Stage IV Non-Small Cell Lung Cancer
NCT00079235 ·Status: COMPLETED ·Phase: PHASE2
-
Experiences w/ & Attitudes Towards Immune Chckpt Inhibitors in NSCLC Patients Single Center Survey Based Study
NCT07339254 ·Status: RECRUITING
-
Sorafenib in Treating Patients With Extensive Stage Small Cell Lung Cancer
NCT00182689 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy Trial of Gemcitabine Containing Regimens As Preoperative Chemotherapy in Non Small Cell Lung Cancer
NCT00191256 ·Status: COMPLETED ·Phase: PHASE2
-
BAY 59-8862 in Treating Patients With Non-Small Cell Lung Cancer
NCT00054314 ·Status: COMPLETED ·Phase: PHASE2
-
CPI-613 in Treating Patients With Relapsed or Refractory Small Cell Lung Cancer
NCT01931787 ·Status: COMPLETED ·Phase: PHASE1
-
C-TIL051 in Non-Small Cell Lung Cancer
NCT05676749 ·Status: TERMINATED ·Phase: PHASE1
-
Study of Pazopanib and Paclitaxel in Advanced Non-small Cell Lung Cancer
NCT00866528 ·Status: COMPLETED ·Phase: PHASE1
-
Safety and Efficacy of BKM120 in Patients With Metastatic Non-small Cell Lung Cancer
NCT01297491 ·Status: COMPLETED ·Phase: PHASE2