Using Ex Vivo Tumoroids To Predict Immunotherapy Response In NSCLC
NCT05332925 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 25
Last updated 2024-02-23
Summary
To test whether it is feasible to perform the 3D-EX functional predictive response bioassay in the context of patients with advanced/metastatic NSCLC receiving immune checkpoint inhibitors in the standard of care clinical setting.
Conditions
- Lung Cancer
- NSCLC
- NSCLC Stage IV
Interventions
- DRUG
-
Standard of care immune checkpoint inhbitors
This is NOT an interventional study.
Sponsors & Collaborators
-
Nilogen Oncosystems
collaborator INDUSTRY -
Jun Zhang, MD, PhD
lead OTHER
Principal Investigators
-
Jun Zhang, MD, PhD · University of Kansas Medical Center
Eligibility
- Min Age
- 18 Years
- Max Age
- 110 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-07-21
- Primary Completion
- 2026-01-31
- Completion
- 2027-02-28
Countries
- United States
Study Locations
More Related Trials
-
Organoid-guided vs Topotecan Therapy in Relapsed Extensive-Stage Small Cell Lung Cancer
NCT07106528 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2/PHASE3
-
Genetically Engineered Natural Killer (NK) Cells With or Without Atezolizumab for the Treatment of Non-small Cell Lung Cancer Previously Treated With PD-1 and/or PD-L1 Immune Checkpoint Inhibitors
NCT05334329 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Safety and Efficacy Clinical Study of SNS-595 for Second-Line Therapy in Patients With Advanced NSCLC
NCT00252382 ·Status: COMPLETED ·Phase: PHASE2
-
Study of CTDNA Response Adaptive Immuno-Chemotherapy in Lung Cancer
NCT04093167 ·Status: RECRUITING ·Phase: PHASE2/PHASE3
-
Safety and Efficacy Clinical Study of SNS-595 in Patients With Advanced Small Cell Lung Cancer
NCT00298896 ·Status: COMPLETED ·Phase: PHASE2
-
Autologous Tumor DRibble Vaccine in Patients With Non-Small Cell Lung Cancer
NCT00850785 ·Status: COMPLETED ·Phase: PHASE1
-
A Study Evaluating the Efficacy and the Safety of First-line Chemotherapy Combined With the Therapeutic Vaccine Named TG4010 and Nivolumab in Patients With Advanced Non-squamous Non-Small Cell Lung Cancer (NSCLC)
NCT03353675 ·Status: COMPLETED ·Phase: PHASE2
-
A Single-cell Approach to Identify Biomarkers of Efficacy and Toxicity for ICI in NSCLC
NCT04807114 ·Status: RECRUITING
-
Evaluation of Efficacy and Toxicity of Nivolumab Monotherapy for Advanced Non-small Cell Lung Cancer After First-line Treatment Failure Based on Second-generation Sequencing and Liquid Chip Platform
NCT03692442 ·Status: UNKNOWN
-
Phase I/II Eval Safety & Prelim Activity Nivolumab Comb W/Vorolanib Pts W/Refractory Thoracic Tumors
NCT03583086 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Safety and Efficacy of Adebrelimab Plus Irinotecan Liposome (II) With or Without Famitinib in ES-SCLC Pre-treated With Immunotherapy
NCT06332950 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
Azacitidine and Entinostat Before Chemotherapy in Treating Patients With Advanced Non-small Cell Lung Cancer
NCT01935947 ·Status: TERMINATED ·Phase: PHASE2
-
Patient-derived Tumor-like Cell Cluster Model-based Precision Treatment Strategy on Non-small Cell Lung Cancer
NCT07328945 ·Status: RECRUITING
-
Immune Profile Selection By Fraction of ctDNA in Patients With Advanced NSCLC Treated With Immunotherapy
NCT05715229 ·Status: RECRUITING ·Phase: PHASE2
-
To Immunize Patients With Extensive Stage SCLC Combined With Chemo With or Without All Trans Retinoic Acid
NCT00617409 ·Status: COMPLETED ·Phase: PHASE2
-
STRIVE: A Single-arm Phase 2 Study on Treatment of Lung Squamous Cell Carcinoma by Tiragolumab Plus Ivonescimab for Patients Who Progressed on Platinum Doublets and Anti-PD-1/PD-L1
NCT07038915 ·Status: WITHDRAWN ·Phase: PHASE2
-
Study of the Efficacy of an Investigational Drug in Adult Patients With Non Small-Cell Lung Cancer (NSCLC)
NCT00034957 ·Status: COMPLETED ·Phase: PHASE2
-
Tocilizumab and Atezolizumab in Adults With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Refractory to 1st Line Immune Checkpoint Inhibitor-Based Therapy
NCT04691817 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Vaccine Treatment for Advanced Non-Small Cell Lung Cancer
NCT00073398 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Use Peripheral Blood Proteomics to Predict the Treatment Response and Toxicities in NSCLC Immunotherapy
NCT03951012 ·Status: TERMINATED
-
Safety and Immunogenicity of Recombinant DNA and Adenovirus Expressing L523S Protein in Early Stage Non-Small Cell Lung Cancer
NCT00062907 ·Status: UNKNOWN ·Phase: PHASE1
-
Evaluation of BAY 59-8862 in Taxane Resistant Non-Small Cell Lung Cancer Patients
NCT00044538 ·Status: COMPLETED ·Phase: PHASE2
-
Effect of Infusion Timing on Pathologic Response to Neoadjuvant Immunotherapy in Resectable Non-Small Cell Lung Cancer
NCT07251582 ·Status: RECRUITING ·Phase: PHASE3
-
Tiragolumab With Atezolizumab Plus Bevacizumab in Previously-Treated Advanced Non-squamous NSCLC
NCT04958811 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Combined Statin and PD-1/PD-L1 Inhibitors in Treating Non-small Cell Lung Cancer
NCT05636592 ·Status: ACTIVE_NOT_RECRUITING