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Study of the Microbiological Profile of Stool in Patients With Anorexia Nervosa

NCT03736642 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2020-07-30

No results posted yet for this study

Summary

Anorexia nervosa is an eating disorder whose symptomatology induces a modification of the intestinal microbiota. To date, studies have shown variable profiles without linking them to metabolic and neuropsychological energy phenotyping. This intestinal dysbiosis could be involved in the maintenance of the disorders. Bidirectional communication channels exist between the microbiota, the intestine and the brain. Anomalies in these pathways could explain the impact of the microbiota on the pathophysiology of anorexia nervosa. Therapeutic interventions would then be possible to restore the microbiota in anorexia nervosa and influence the treatment of this disease. This study aims to explore the hypothesis of disruption of the microbiota-intestinal-brain axis transversely and measuring the intestinal microbiota, urinary metabolome, biological factors nutritional, immunological and physiological plasma plasma of the intestine, and finally, the psychological dimensions characteristic of anorexia nervosa.

Conditions

  • Anorexia Nervosa
  • Eating Disorder

Interventions

BIOLOGICAL

blood sampling

12 ml sample

OTHER

stool sampling

20 g sample

OTHER

urine sampling

18 ml sample

DIAGNOSTIC_TEST

neuropsychological tests

* Go-nogo * flexibility * food stroop * implicit and explicit evaluation * Child Depression Inventory * Hamilton Depression Rating Scale

Sponsors & Collaborators

  • Centre Hospitalier Universitaire de Saint Etienne

    lead OTHER

Principal Investigators

  • Natacha GERMAIN · CHU de Saint Etienne

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-05-15
Primary Completion
2019-05-15
Completion
2019-05-15

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03736642 on ClinicalTrials.gov