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Interoception in Anorexia Nervosa

NCT04981626 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2022-07-26

No results posted yet for this study

Summary

Anorexia nervosa is a serious psychiatric illness whose causes remain poorly understood, and which remains difficult to treat to this day. Many clinical manifestations of this disease can have their origin in abnormalities in the perception of signals coming from inside the body, but this remains to be demonstrated. In recent years, research in healthy subjects has shown how the brain constantly perceives the viscera (heart, lungs, stomach). The examiners will use these new, objective and validated methods to explore how the brain processes information from the viscera (interoception) in anorexic patients. In practice, they will quantify the coupling between the cardiac cycle and involuntary eye movements, as well as between the respiratory cycle and voluntary actions such as pressing a button. Finally, by simultaneously recording the electrical activity of the brain, and that of the stomach, the examiners will measure the coupling between the brain and the stomach. All these measurements, which will be compared between a population of patients and healthy subjects, will make it possible to determine whether anorexic patients have an alteration in the perception of their internal body signals and whether this damage affects several organs.

Conditions

  • Anorexia
  • Anorexia Nervosa
  • Electrocardiogram
  • EEG

Interventions

OTHER

Clinical and experimental session

Psychologic profile with standardized interview and scales (see below for details: SCID, BDI, STAI, BPQ, EDE Q, Pictorial Body Image Scale (PBIS) and EDI). Measure the stomach-brain synchrony during EEG/EGG resting state, the distribution of voluntary actions across the respiratory phase, and the distribution of saccadic eye movements across the cardiac-cycle.

Sponsors & Collaborators

  • Laboratoire de Psychologie et NeuroCognition

    collaborator OTHER

  • University Hospital, Geneva

    collaborator OTHER

  • Fondation Santé des Étudiants de France

    lead OTHER

Principal Investigators

  • Marco Solca, Dr · ENS

Eligibility

Min Age
16 Years
Max Age
25 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-02-14
Primary Completion
2022-10-31
Completion
2023-04-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04981626 on ClinicalTrials.gov