The Effect of Iodine Intakes on Maternal and Infant Health and the Study of Iodine RNI for Different Stages of Pregnancy

Summary

This study determined the effects of different iodine intake on the maternal and infant health and provide evidence for studying the RNI and UL of iodine in pregnant women.

1. The study of effect on mothers and their infants of the lack of iodine at different gestation in adequate iodine area.

The purpose of this study was to detect the maternal thyroid function, growth and neuropsychological development of infants in different pregnancy women with diverse iodine intake levels, and to make a clear evaluation for the influence of iodine deficiency during different pregnancy by following up iodine suitable early pregnancy women and mild iodine deficient three pregnancy women as well as their infants.
2. The study of recommended iodine intake (RNI) for healthy pregnant women in three pregnancy.

Different pregnancy women with different iodine intake levels were recruited and carried out iodine balance experiment in the case of not interfering with their diet. In addition, the iodine intake of the pregnant women when they reached "zero iodine balance" was calculated, that was EAR of iodine in pregnant women. In conclusion, the iodine balance experiment in pregnant women at different pregnancy improved the sample collection methods and evaluation criteria and was more scientific and reasonable than the classic iodine balance experiment.
3. The study of effect of different levels of high iodine exposure on pregnant women, delivery women and their infants.

In this study, we made a prospective study of the early pregnancy women and their infants exposed to different high iodine levels in high water iodine areas. At first we defined the effects of long-term iodine excess exposure on the health of the mother and the infants by combining with the reference index of the normal value of the thyroid function in different maternal and postpartum periods, the level of growth and development of the offspring and the assessment of the level of neuropsychological development. Furthermore the harmful effects of different high levels of iodine exposure on pregnant women was synthetically analyzed. This study obtained the safe intake level of iodine for pregnant women and provided scientific basis for the formulation of iodine UL in pregnant women in China.

Conditions

• Iodine Reaction
• Iodine Compounds Overdose
• Pregnancy Related

Interventions

OTHER

Natural exposure of deficient or excessive iodine

Natural exposure of deficient iodine from diet \& drinking water, and of excessive iodine intake from drinking water

Sponsors & Collaborators

• Shandong Institute for Endemic Disease Control and Research

  collaborator UNKNOWN

• Tianjin Maternal and Child Health Care Center

  collaborator UNKNOWN

• Wanqi Zhang

  lead OTHER

Principal Investigators

• Ping Shao, Master · Tianjin Maternal and Child Health Care Center

• Xiaoming Wang, Master · Shandong Institute for Endemic Disease Control and Research

• Laixing Lin, Master · Tianjin Medical University Metabolic Diseases Hospital

• Jun Shen, Master · Tianjin Medical University

• Long Tan, PhD · Tianjin Medical University

• Wen Chen, PhD · Tianjin Medical University

• Wei Wang, BA · Tianjin Medical University

• Tingkai Cui, BA · Tianjin Medical University

• Min Gao, BA · Tianjin Medical University

• Yanting Chen, BA · Tianjin Medical University

• Wenxing Guo, BA · Tianjin Medical University

• Chongdan Wang, BA · Tanggu Maternity Hospital

Eligibility

Min Age

18 Years

Max Age

35 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2014-01-01

Primary Completion

2018-12-31

Completion

2020-12-31

Countries

• China

Study Locations