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Genicular Nerve Block for Total Knee Arthroplasty

NCT03706313 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2021-04-01

Study results available
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Summary

This study seeks to examine the analgesic efficacy of genicular nerve blocks for pain after total knee replacement.

Conditions

  • Post-operative Pain

Interventions

DRUG

15mL 0.25% bupivacaine

Patients will be randomly assigned to either a genicular nerve block with bupivacaine or saline

PROCEDURE

Genicular nerve block

The ultrasound-guided genicular nerve block will be performed at the site of the superior lateral, the superior medial, and the inferior medial genicular nerves. Color Doppler will be used to identify the arterial structures which serve as landmarks for the corresponding nerves. After skin local anesthetic infiltration, a 10 cm 21G insulated block needle will be inserted and aligned with the ultrasound scanning plane. Once satisfactory position of the needle is confirmed, 5mL of a solution containing 15 ml of 0.25% bupivacaine with 2mg dexamethasone or 5mL saline will be slowly injected. Spread of local anesthetic will be documented adjacent to the target nerve. This procedure will be performed at the site of the three genicular nerves described.

DRUG

Saline

Patients will be randomly assigned to either a genicular nerve block with bupivacaine or saline

Sponsors & Collaborators

Principal Investigators

  • Jeffrey Gadsden, MD · Duke University

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-01-15
Primary Completion
2019-10-16
Completion
2019-10-22
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03706313 on ClinicalTrials.gov